منابع مشابه
Osteoporotic Changes and Alteration of Osteoblast and Osteoclast Distribution in Aging Syndecan-4 Deficient Mice
Introduction: Osteoporosis today turns out to be one of the most cost intensive musculoskeletal diseases worldwide. Recent research contributes to our understanding of the regulatory mechanism of bone biology and osteoporotic pathogenesis, but many details remaine unclear. In this study, a member of the transmembrane heparansulfate proteoglycan family of Syndecans, Syndecan-4, appears to functi...
متن کاملImpaired Osteoblast Function in GPRC6A Null Mice
GPRC6A is a widely expressed orphan G protein-coupled receptor that senses extracellular amino acids, osteocalcin, and divalent cations in vitro. GPRC6A null (GPRC6A(-/-)) mice exhibit multiple metabolic abnormalities including osteopenia. To investigate whether the osseous abnormalities are a direct function of GPRC6A in osteoblasts, we examined the function of primary osteoblasts and bone mar...
متن کاملGsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice.
The heterotrimeric G protein subunit Gsα stimulates cAMP-dependent signaling downstream of G protein-coupled receptors. In this study, we set out to determine the role of Gsα signaling in cells of the early osteoblast lineage in vivo by conditionally deleting Gsα from osterix-expressing cells. This led to severe osteoporosis with fractures at birth, a phenotype that was found to be the conseque...
متن کاملChanges of serum level of acetylcholinesterase enzyme in lipopolysaccharide-induced model of depression in mice
Background and Objective: Depression is a common disorder, especially in developed countries. Functional changes of cholinesterase are involved in pathogenesis of some brain disorders. Until now, exact association of these changes with depression has not been determined. This study was conducted to evaluate the changes of serum cholinesterase in lipopolysaccharide (LPS)-induced model of depress...
متن کاملNucleoli and AgNORs in Hodgkin's disease.
AIM To evaluate the morphofunctional characteristics of lymph node cells from patients with Hodgkin's disease by measuring silver stained nucleolar organiser regions (AgNORs). METHODS Nucleoli in Hodgkin's and Reed-Sternberg (HRS) cells, lymphocytes and prolymphocytes were investigated in cytological smears and histological sections of lymph nodes from 32 patients with Hodgkin's disease, and ...
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ژورنال
عنوان ژورنال: The Journal of the Kyushu Dental Society
سال: 1996
ISSN: 0368-6833,1880-8719
DOI: 10.2504/kds.50.705